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The Hydrocephalus and Neuroscience Institute formally known as Wade’s Center for Hydrocephalus was organized by Dr. Jogi Pattisapu to conduct research into the underlying cause of hydrocephalus. The lab, which has a primary research focus of understanding cerebrospinal fluid circulation and developing new strategies and novel treatments for hydrocephalus is located at the University of Central Florida Burnett School of Biomedical Sciences. For the past two and a half years, the lab team has been investigating therapeutic interventions, alternative CSF pathways, and molecular alterations using a congenital rodent model of hydrocephalus


To support research that will further the understanding of hydrocephalus, offer opportunities for improved therapeutic management and/or discover a cure for this disorder.


Current research focus:

Cilia - Novel insights into the ciliary transport processes can lead to improved understanding of CSF homeostasis. HYDIN (hydrocephalus gene) and cilia are ideal candidates to investigate ciliary transport pathways because of their association with hydrocephalus. The team expects to identify novel ciliary disease proteins and candidate genes that interact with HYDIN and TSGA10 which may be involved with CSF homeostasis and circulation in the brain.

Aquaporin Channels - Aquaporins (AQP) are a family of highly important membrane proteins that are bidirectional pathways that transport fluid. These channels are believed to play an important role in the pathophysiology of brain edema and hydrocephalus, and the goal is to discover a drug or other method to recruit these channels to function as gateways for CSF

We also sponsor A Hydrocephalus Family Support Group whose mission is to increase understanding and awareness and provide a forum for families to learn, voice concerns, and share experiences. The Support Group conducts meetings and holds fundraising activities to provide funding for hydrocephalus research.


Hydrocephalus occurs at a high frequency (up to 1 per 500 live human births), and provides the main impetus for a detailed investigation of this fluid pathway. Furthermore, studies have demonstrated that fetal CSF is vital to normal development of the cerebral cortex. Shunting, although relieving the high pressure due to fluid accumulation, does not reinstate normal flow.

Thus, it is vital to understand the normal functional anatomy of the CSF fluid system and how it goes wrong in hydrocephalus, in order to determine the best strategies for treatment and alleviation of the many consequences of fluid obstruction. Our hope is that this research will further the understanding of hydrocephalus, and offer opportunities for improved therapeutic management of this disorder.


Jogi V. Pattisapu, MD, FAAP, FACS is a Pediatric Neurosurgeon for Childhood Neurosurgery & Center for Hydrocephalus, PA. He also serves as a foundation board member for Florida Children’s Hospital, and as an Associate Professor for The U.C.F. College of Medicine at Burnett School of Biomedical Sciences where he conducts hydrocephalus research.

He obtained his medical degree in 1981 from University of Texas Medical Branch. In 1986, he completed his residency in Neurosurgery from the University of Mississippi School of Medicine and Pediatric Neurosurgery Fellowship at The University of Utah School of Medicine. He was Chief of Pediatric Neurosurgery from 1988-1990 at Temple University School of Medicine in Philadelphia.

Dr. Pattisapu holds certifications from the American Board of Neurological Surgery and the American Board of Pediatric Neurological Surgery. In addition to his private practice and research activities, Dr. Pattisapu has been in the Orlando area for over 17 years and is actively involved in local community projects such as The Hydrocephalus Family Support Group and Safe Kids of Greater Orlando.


Interim Executive Director – Kimberlee Antonetti, LPN
9017 Montevello Court, Orlando, FL

Medical Director - Jogi V. Pattisapu, MD, FAAP, FACS
338 Oak Estates Drive, Orlando, FL

Medical Advisor – Christopher Gegg, MD
9815 Buckhead Court
Windermere, FL 32780

Medical Advisor – Annapurna Pattisapu, MD
338 Oak Estates Drive, Orlando FL

Treasurer – Michael Rushman, MBA
1501 Gladiolis Drive, Winter Park, FL

Board Member- Steven Ira
1064 Green wood Blvd Ste 328
Lake Mary, FL

Board Member- Larry Phillips
10082 Halls River Rd, Homosassa, FL


United States




ORLANDO, FL 32806-4453
Phone: (407) 649-6474
EIN: 20-3805294

A Gift Card

Cure Hydrocephalus

Research at $535/day

Your donation will help put us one step closer to finding a cure for hydrocephalus. Since the government gives almost no funding toward meaningful Hydrocephalus research, hope for a cure has been hard to come by. Most research being done is focused on creating a new type of shunt; since treating a condition is much more profitable than curing one. In the entire United States,...